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Writer's pictureCorinne Weber

Inside Out: Understanding the Neurobiology of Eating Disorders

Updated: Sep 17

As an ever-evolving human being, I am always seeking new information that helps me grow. As a clinician, I am naturally curious about knowledge that can benefit my clients—especially when it comes to eating disorders. Having come full circle in my own recovery, I often find myself drawn to the question of why. Why did I develop an eating disorder? What factors made me vulnerable, and why couldn’t I just stop? These are difficult questions to reflect on, but crucial to understanding the complexities of this condition.


Recently, I had the opportunity to attend a conference hosted by the Eating Recovery Center in San Jose, California. The conference focused on eating disorders and traumatic stress, but what intrigued me most was the presentation on the neurobiological foundations of eating disorders, particularly Binge Eating Disorder (BED). I left with a deeper understanding of the brain’s role in these disorders, and today I want to share that knowledge with you.


The Neurobiology of Eating Disorders

When we think about eating disorders, we often focus on the behaviors—restricting food, bingeing, purging. But what many people don’t realize is that these disorders are deeply rooted in the brain. Significant changes occur within the brain when someone is struggling with an eating disorder, and these changes can perpetuate the disorder, making it incredibly difficult to break free without help.

Here’s a brief overview of the neurobiological factors associated with three of the most common eating disorders:


Anorexia Nervosa (AN)

  • Characterized by extreme food restriction, intense fear of gaining weight, and a distorted perception of body image.

  • Anorexia has the highest mortality rate of all psychiatric illnesses.

Neurobiology of AN:

  • Prolonged underweight status affects the brain, impairing attention, concentration, and problem-solving abilities.

  • The brain’s insula, which is responsible for body awareness, enlarges. This leads to distorted body image and a diminished sense of hunger and fullness.

  • Neurotransmitters like dopamine and serotonin, which regulate mood and social behavior, are disrupted, contributing to anxiety around food and a lack of emotional awareness.

Bulimia Nervosa (BN)

  • Involves periods of binge eating followed by purging behaviors (vomiting, excessive exercise, laxative use) to compensate for overeating.

  • Individuals with BN often struggle with impulse control and engage in pleasure-seeking behavior despite the consequences.

Neurobiology of BN:

  • Brain scans show differences in the prefrontal cortex, which affects attention and planning.

  • Lower dopamine levels are associated with increased binge-purge cycles. After a binge, dopamine spikes, creating a temporary sense of reward, which reinforces the behavior.

Binge-Eating Disorder (BED)

  • The most common eating disorder, characterized by eating large quantities of food in a short period, often to the point of discomfort, followed by feelings of guilt or shame.

Neurobiology of BED:

  • Brain activity changes in areas related to impulsivity and compulsivity. Initially, food provides a heightened sense of reward, but as the disorder progresses, more food is required to achieve the same pleasure.

  • Lower dopamine levels in the brain’s reward centers lead to compulsive eating, similar to how addiction works.


So, What Does This All Mean?

One of the most important takeaways from this information is that individuals suffering from eating disorders are not at fault. These disorders are not a choice. They are rooted in both genetic predispositions (which account for 40%-60% of the risk) and neurobiological changes within the brain. These complex brain alterations make it extremely difficult for someone to simply “stop” their behaviors, as the brain’s reward systems and impulse controls have been significantly affected.


There is Always Hope

While the science behind eating disorders can feel daunting, it’s crucial to remember that recovery is possible. Therapy, along with a variety of support systems, can help individuals regain control over their lives and begin the process of healing.


If you or someone you love is struggling with an eating disorder, know that there is hope. Recovery may be challenging, but with persistence, it is achievable. For those fighting this battle, keep going. And for those who love someone suffering from an eating disorder, know that your support makes a world of difference. Sit beside them, encourage them, and never lose hope—recovery is within reach.


Understanding the neurobiological underpinnings of eating disorders reminds us that these conditions are not about willpower or vanity—they are rooted in real, physical changes within the brain. Armed with this knowledge, we can approach treatment with more compassion and confidence, knowing that healing is not only possible, but also within reach for anyone willing to take that step.

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